Set in the year 2047, Prophet has embarked upon a revenge mission after uncovering the truth behind Cell Corporation's motives for building the quarantined Nanodomes. The citizens were informed that the giant citywide structures were resurrected to protect the population and to cleanse these metropolises of the remnants of Ceph forces. In reality, the Nanodomes are CELL's covert attempt at a land and technology grab in their quest for global domination. With Alien Ceph lurking around every corner and human enemies on the attack, nobody is safe in the path of vengeance. Everyone is a target in Prophet's quest for retribution.